🍬 Endothelium Under Attack: The Sweetener-Inflammation Link
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 New Findings on Aspartame & Heart Health! 🍬🫀
A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis.
🧪 Key insights from mice and monkeys:
– Aspartame spikes insulin via vagus nerve stimulation
– Elevated insulin boosts CX3CL1 expression in endothelial cells
– CX3CL1 recruits inflammatory monocytes ➡️ plaque growth & instability
🧬 Blocking CX3CR1 in monocytes stopped plaque progression entirely.
⚠️ Implications for diabetics, sweetener users, and those at risk of cardiovascular disease are profound.
#Atherosclerosis #Aspartame #Cardiology #PrecisionMedicine #Inflammation #Insulin #CX3CL1 #MedicalResearch #Podcast #CardioMetabolism