🪙 Double Trouble or Dual Protection? 💊💊🛡️ Ticagrelor and Aspirin After CABG—What Did We Learn?
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🧠 TACSI Trial in NEJM (Sep 2025) challenges the status quo on dual antiplatelet therapy after CABG for ACS!
👨⚕️ 2201 patients across 5 Nordic countries
💊 Ticagrelor + Aspirin ≠ better outcomes vs Aspirin alone
📉 No reduction in death, MI, stroke, or revascularization
🩸 But bleeding (4.9% vs 2.0%) & dyspnea (18.2% vs 6.4%) increased
📚 Guidelines may need rethinking.
📖 Jeppsson A et al. N Engl J Med. 2025; DOI: 10.1056/NEJMoa2508026
#TACSI #Cardiology #CABG #DAPT #ACS #NEJM #PrecisionMedicine #RCT #BleedingRisk #ClinicalTrials