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Chronic lymphedema may not just be about fluid. It may be about cholesterol. 🧬

Chronic lymphedema may not just be about fluid. It may be about cholesterol. 🧬

Dr RR Baliga's "Got Knowledge Doc" Podkast

February 16, 20266m 5s

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Show Notes

Chronic lymphoedema may not just be about fluid. It may be about cholesterol. 🧬

In human tissue and translational mouse models, impaired lymphatic drainage led to excess dermal cholesterol deposition, adipocyte dysfunction, fibrosis, and swelling — even when plasma cholesterol was normal.

Clearing tissue cholesterol with cyclodextrin restored lymphatic architecture and reduced oedema.

Clear the cholesterol. Restore the flow