🧠 Can the aging brain still make new neurons?
Dr RR Baliga's "Got Knowledge Doc" Podkast
February 27, 20264m 7s
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Show Notes
Can the aging brain still make new neurons?
A landmark 2026 Nature study analyzed 355,997 human hippocampal nuclei using single-nucleus RNA sequencing and ATAC sequencing. Neurogenesis persists into adulthood—but chromatin accessibility collapses early in Alzheimer's disease.
SuperAgers showed a 2.5-fold increase in immature neurons and a preserved resilience signature.
Epigenetics may be the earliest battlefield in cognitive decline. 🧠