Calcium-Free ≠ Risk-Free ❌💔: 🫀🔍 LDL-C's Silent Strike in CAC = 0
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 New Study Alert 🧬🫀
Think a CAC score of zero means you're in the clear? Think again.
A massive cohort from the Western Denmark Heart Registry (n = 23,777) shows that elevated LDL-C is strongly associated with non-calcified plaque 🧱 and future coronary events 💥—even in those with CAC = 0.
📈 Each 1 mmol/L (~39 mg/dL) rise in LDL-C increases the odds of plaque (aOR 1.21) and risk of CHD (aHR 1.28).
🔥 Risks were highest in individuals ≤45 years—a silent threat during prime decades of life.
💡 Takeaway: No calcium ≠ No risk. LDL-C still drives subclinical disease.
👩⚕️👨⚕️ Time to rethink statin strategy in younger adults with "reassuring" scans.
📚 Read more in European Heart Journal (2025):
👉 https://doi.org/10.1093/eurheartj/ehaf497
#LDL #CAC #Cardiology #Atherosclerosis #CHD #Prevention #Lipidology #CCTA #PrecisionMedicine #Statins #EHJ #SubclinicalDisease #CardioLinked