Beyond the Golden Hour ⏳🧬🧠: Late Lysis, Salvageable Tissue, Better Outcomes, But At a Price
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 New Stroke Trial Alert! 🧠💉
Can IV alteplase help beyond the 4.5-hour mark? The HOPE trial (JAMA 2025) says YES—if perfusion imaging shows salvageable brain tissue 🧬🕑.
📊 Functional independence at 90 days improved from 26% ➡️ 40%, despite a small uptick in symptomatic ICH (3.8%).
🌍 Game-changer for patients in low-resource settings where thrombectomy isn't an option.
📖 Read more: https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.12063
#StrokeCare #Thrombolysis #Alteplase #Neuroimaging #HOPEtrial #JAMA #StrokeResearch #GlobalHealth #BrainRescue #MedicalInnovation