A Molecular Autopsy in Real Time 🧬⏱️Checkpoint Inhibitors, Multiorgan Damage ♟️🧬⚠️
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🧬 When immunity saves—and harms—at the same time
A striking NEJM correspondence reveals that patients receiving immune checkpoint inhibitors often sustain molecularly detectable multiorgan damage—weeks to months before symptoms appear. Using cell-free DNA methylation mapping, investigators show that immune-related adverse events are systemic, not isolated organ toxicities—the visible clinic finding is just the tip of the iceberg 🧊🧬
This work reframes irAEs as a global loss of immune tolerance and opens the door to early, molecular surveillance—particularly relevant for cardio-oncology and precision medicine.
📍 Source: The New England Journal of Medicine, December 2025
#Immunotherapy #CardioOncology #PrecisionMedicine #cfDNA #NEJM #TranslationalScience