A Blood Test Before Symptoms: PPP2R5C and the Molecular Clock of Alzheimer's
Dr RR Baliga's "Got Knowledge Doc" Podkast
February 22, 20264m 31s
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Show Notes
🧠 Alzheimer's doesn't begin when memory fails — it begins years earlier.
A new Cell Reports Medicine study identifies PPP2R5C, a brain-derived protein detectable in blood, that declines before significant Tau hyperphosphorylation.
📉 ↓ 61% in amnestic mild cognitive impairment
📊 AUC 0.85 for Alzheimer's diagnosis
🔬 Mechanism: activates Protein Phosphatase 2A and ULK1-driven autophagy to regulate Tau
A blood signal before symptoms.
Early detection means earlier intervention.