1. 💔🩸⚖️ Aspirin, Anticoagulants & Harm: Rethinking Dual Therapy in Stable CAD
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
💊🫀 Aspirin in the Crosshairs?
The AQUATIC Trial (NEJM, Aug 2025) raises sharp questions on dual-pathway therapy in chronic coronary syndrome (CCS) patients already on long-term anticoagulation.
📉 Adding aspirin led to:
• ↑ Ischemic events (HR 1.53; P=0.02)
• ↑ Mortality (HR 1.72; P=0.01)
• ↑ Major bleeding (HR 3.35; P)
🧠 Takeaway: More isn't always better. In high-risk CCS, aspirin may harm more than help.
📚 Read: https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
#Cardiology #Antiplatelet #NEJM #PrecisionMedicine #AQUATICTrial