How Chronic Stress Increases Risk of Depression
Dr. Joseph Mercola - Take Control of Your Health · Dr. Joseph Mercola
November 8, 20258m 6s
Audio is streamed directly from the publisher (traffic.libsyn.com) as published in their RSS feed. Play Podcasts does not host this file. Rights-holders can request removal through the copyright & takedown page.
Show Notes
- Chronic stress triggers a neutrophil invasion into brain-protective layers, driving depression-like behaviors through immune activation rather than just hormonal changes
- Stress-induced immune signals hijack brain reward circuits, reducing dopamine and shifting neural activity toward threat detection over pleasure-seeking behaviors
- Prolonged stress damages brain mitochondria, reducing cellular energy production while creating an inflammatory feedback loop that worsens mood and cognitive function
- Interferon pathways and inflammatory cytokines like IL-6 cross into the brain, directly altering neuron firing patterns in emotional regulation centers
- Natural interventions including healthy carbohydrates, regular exercise, positive thinking, creativity, and physical touch help counter stress-induced immune activation and protect mental health