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Key Decisions in HIV Care: Considering the Use of Proviral DNA Genotyping to Inform ART Choice
Episode 127

Key Decisions in HIV Care: Considering the Use of Proviral DNA Genotyping to Inform ART Choice

Listen as John D. Baxter, MD, shares the latest data and recommendations for the use of proviral HIV DNA genotyping to inform ART choice for patients with significant ART experience.

Decera Clinical Education Infectious Disease Podcast · John D Baxter MD

February 1, 202217m 56s

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Show Notes

In this episode, John D. Baxter, MD, explores recommendations and data on the use of proviral DNA genotyping to inform antiretroviral therapy (ART) choice for patients who are treatment experienced.

Listen as he gives his perspectives on:

  • US Department of Health and Human Services guideline recommendations on the use of proviral DNA genotyping
  • US Department of Health and Human Services guideline recommendations and supporting data on switching ART with viral suppression and underlying drug resistance
  • Study 380-4030 on outcomes with bictegravir- and dolutegravir-based ART in patients with preexisting nucleos(t)ide reverse-transcriptase inhibitor resistance
  • The BRAAVE 2020 study on switching to bictegravir/emtricitabine/tenofovir alafenamide in Black persons with HIV, some of whom had baseline ART resistance
  • Between-class ART switches with underlying resistance
  • Susceptibility of tenofovir disoproxil fumarate and abacavir with thymidine analogue mutations

Presenter:

John D. Baxter, MD
Professor of Medicine
Division of Infectious Diseases
Department of Pathology
Cooper Medical School of Rowan University
Head, Division of Infectious Diseases
Cooper University Health Care
Camden, New Jersey

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Topics

dolutegravirngsintegrase inhibitorbicstudy 1824braave 2020next-generation sequencingdrug resistancedna genotypedtgarchive genotypedhhs guidelinesproviral dna genotypeintegrase strand transfer inhibitorbictegravirantiretroviral therapyproviral genotypeart resistanceinstiresistancebraavestudy 380-4030treatment-experiencedsuppressedarchived resistancearthivart switch