Investigational Dual PPAR Agonist, FXR Agonist With Fibrate, and Hyperlipidemia in People With PBC: Conference Coverage of AASLD
Listen as Marlyn J. Mayo, MD, discusses exciting new data from AASLD 2023 for people with PBC, including a late-breaking study of a dual PPAR agonist, biochemical response rates in people treated with an FXR agonist with or without a fibrate as second-line therapy, and evaluation of hyperlipidemia, atherosclerosis, and hepatic steatosis in people with PBC.
Decera Clinical Education Infectious Disease Podcast · Marlyn J Mayo MD
Audio is streamed directly from the publisher (afp-928689-injected.calisto.simplecastaudio.com) as published in their RSS feed. Play Podcasts does not host this file. Rights-holders can request removal through the copyright & takedown page.
Show Notes
During the 2023 American Association of the Study of Liver Diseases (AASLD) conference, exciting and important results from many primary biliary cholangitis (PBC) clinical trials were reported, including 3 late-breaking studies on the PPAR-delta agonist seladelpar, the dual PPAR agonist elafibranor, and the combination of the FXR agonist obeticholic acid and a fibrate.
In this episode, Marlyn J. Mayo, MD, discusses topline results from several of these studies and more, including:
- A phase III study of an investigational dual PPAR α/δ agonist (elafibranor) in people with PBC who did not respond to or were intolerant of ursodeoxycholic acid (UDCA)
- A study that evaluated the effectiveness and safety of second-line therapy in PBC where obeticholic acid with or without a fibrate was added to the treatment regimen of people with PBC with an incomplete response to UDCA
- A retrospective review of the rates of hyperlipidemia, atherosclerosis, and/or hepatic steatosis in patients with PBC
Presenter:
Marlyn J. Mayo, MD
Professor of Internal Medicine
Division of Digestive & Liver Diseases
UT Southwestern Medical Center
Dallas, Texas
Link to commentary:
https://bit.ly/47PmGdc
Link to reviews of other PBC studies from AASLD 2023:
https://bit.ly/3RvXXEI
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.