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FAQs: Improving Empiric Antibiotic Regimens for HABP/VABP in the ICU
Episode 224

FAQs: Improving Empiric Antibiotic Regimens for HABP/VABP in the ICU

Hear from expert faculty as they answer questions and discuss key considerations when selecting empiric antibiotic therapy in patients with HABP/VABP in the ICU.

Decera Clinical Education Infectious Disease Podcast · Marion Elligsen BScPhm MSc RPh ACPR, Keith S Kaye MD MPH, Andrew Shorr MD MPH MBA

December 6, 202230m 47s

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Show Notes

In this episode, Marion Elligsen, BScPhm, MSc, RPh, ACPR; Keith S Kaye, MD, MPH; and Andrew Shorr, MD, MPH, MBA, discuss key considerations for selecting empiric antibiotic regimens in patients with HABP/VABP in the intensive care unit, including: 

  • The role of novel β-lactam/β-lactamase inhibitor combinations
  • Use of clinical predictions scores (eg, Drug Resistance in Pneumonia [DRIP] score) to predict risk for pneumonia caused by multidrug-resistant pathogens
  • Application of rapid diagnostic testing in critically ill patients with pneumonia, including current limitations
  • Implementation of advanced antibiograms and clinical prediction scores
  • Clinical utility of biomarkers for pneumonia (eg, procalcitonin)
  • Application of updated nosocomial pneumonia classifications in clinical practice

Faculty:
Marion Elligsen, BScPhm, ​ MSc, RPh, ACPR​
Practice-Based Researcher
Sunnybrook Research Institute​
Antimicrobial Stewardship Pharmacy Lead
Department of Pharmacy​
Sunnybrook Health Sciences Centre​
Toronto, Ontario, Canada​

Keith S. Kaye, MD, MPH
Chief  
Division of Allergy, Immunology and Infectious Diseases
Professor of Medicine
Rutgers Robert Wood Johnson Medical School
New Brunswick, New Jersey

Andrew Shorr, MD, MPH, MBA​
Director
Pulmonary and Critical Care Medicine​
Medstar Washington Hospital Center​
Washington, DC​

Content based on a CME program supported by an educational grant from Merck Sharp & Dohme Corp. 

Link to full program:
https://bit.ly/3HaZpYw

Link to downloadable slideset:
https://bit.ly/3UxHoqr


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Topics

refractory hapantibioticventilatoracinetobacterantibiogramextended infusionbeta-lactamcontinuous infusionhcapnosocomialrapid diagnosticsceftolozane/tazobactamcreceftazidime/avibactampneumoniaaminoglycosidessurrogate markervalidationmini-balprocalcitoninbeta-lactamaseempiricbeta-lactamase inhibitorarea under the curvereflex testingidentificationclinical pulmonary infection scorebalceftriaxoneinoculumcolonizerhabp/vabpbiomarkerazithromycinemrsusceptiblecombined antibiogrampathogengfricuescalation antibiogramcaploading dosemdrresistancecefiderocolhospitalhap/vapintensivistnebulizerguidelinesduration of therapydrip scoreaspiration pneumoniaquantitativeoxygenationpseudomonaslong term care facilitypharmacokineticquinoloneanalyticalclinical prediction scorecarbapenemimipenem/relebactam/cilastatin