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DTR-Pseudomonas aeruginosa: Applying Best Practices in Complex Clinical Scenarios
Episode 335

DTR-Pseudomonas aeruginosa: Applying Best Practices in Complex Clinical Scenarios

Hear experts apply the latest data and guidance recommendations on optimizing antimicrobial therapy for complex clinical infections involving Pseudomonas aeruginosa with difficult-to-treat resistance.

Decera Clinical Education Infectious Disease Podcast · Trevor Van Schooneveld MD, Emily Heil PharmD MS BCIDP AAHIVP, Laila Woc Colburn MD

November 16, 202317m 21s

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Show Notes

In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving Pseudomonas aeruginosa with difficult-to-treat resistance, including: 

  • Mechanisms of β-lactam resistance
  • Effect of resistance mechanism on susceptibility to antipseudomonal agent
  • 2023 IDSA guidance recommendations 
  • Activity against newer antipseudomonal β-lactams in the United States
  • The latest clinical data by antimicrobial regimen:

              - Ceftolozane/tazobactam
              - Ceftazidime/avibactam
              - Imipenem/cilastatin/relebactam
              - Cefiderocol

  • Applying antimicrobial stewardship principles

Program Director:

Trevor Van Schooneveld, MD, FSHEA, FACP  
Professor, Division of Infectious Diseases
Program Director, Infectious Diseases Fellowship
Medical Director, Antimicrobial Stewardship Program
University of Nebraska Medical Center
Omaha, Nebraska

Faculty:

Emily Heil, PharmD, MS, BCIDP, AAHIVP
Associate Professor
Department of Pharmacy
University of Maryland  
School of Pharmacy
ID Clinical Pharmacy Specialist
University of Maryland Medical Center|
Baltimore, Maryland

Laila Woc-Colburn, MD
Associate Professor
Division of Infectious Diseases
Emory University School of Medicine  
Atlanta, Georgia

Content based on a CME program supported by an educational grant from Merck & Co., Inc., Rahway, NJ, USA.

Follow along with a downloadable slideset at: https://clinicaloptions.com/CE-CME/infectious-disease/cmv-prevention-in-sot-recipients/26139

Link to full program: https://bit.ly/40HyvPy

 


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Topics

porin mutationsesblceftolozane/tazobactamrestore-imiidsa guidanceceftazidime/avibactamaminoglycosidesantimicrobial stewardshipcarbapenemsretrospective studiesantimicrobial resistancecredible-crcefepimecombination therapyimipenem/cilastatin/relebactamchallengesndmdtr-p. aeruginosaempiric therapynonsusceptibilitybeta-lactamasesmechanisms of resistancerisk factorscompassionate usedelayed therapyimipenemceftazidimeefflux pumpspiperacillin/tazobactamoprdmexab-oprmcefiderocolpolymyxinscactusimpvimgenotypemeropenemnebulized antibioticsampcmblprove