Curbside Consults

Together with Dr. David Harrington, 2018/2019 NEJM Editorial Fellows Angie, Angela, and Amanda summarize and wrap up the NEJM experience.

Missing data are common in randomized, controlled trials. Why does this happen? How do we interpret these missing data? In this episode of Curbside Consults, Dr. David Harrington, statistical editor at the NEJM, joins us for a discussion on missing data and how to interpret missing data in studies.

Osteoporosis affects more than 10 million people living in the United States. Although a number of medications are available for treatment of osteoporosis, it remains undertreated. In this episode of Curbside Consults, Dr. Clifford J. Rosen, Professor of Medicine at Tufts University School of Medicine and Associate Editor at the NEJM, joins us to...

Although randomized controlled trials get much of the attention in journal club, observational studies allow researchers to ask questions that may not be possible with RCTs. In this episode of Curbside Consults, we discuss the strengths and limitations of large observational studies and how to critically appraise them.

In the current era of the opioid epidemic, what role do opioid prescriptions play? With all the scrutiny physicians face when prescribing opioids, what can trainees do to be safe and thoughtful prescribers? Dr. Scott Hadland, Assistant Professor of Pediatrics at Boston University School of Medicine and on the faculty of the Grayken Center for...

Clinical trials can be stopped early for a range of reasons. But when that happens, it can be tricky to interpret the results and to understand the reasons why the trial was stopped in the first place. Join us in this episode of Curbside Consults with Dr. David Harrington, statistical editor at the NEJM, as we discuss...

Intravenous thrombolysis has been an essential component in the management of acute ischemic stroke. Current guidelines recommend that thrombolysis be administered within 3 hours of the onset of first neurologic symptoms. However, two recent trials published in NEJM challenge this time paradigm. In this episode of Curbside Consults...

Practical or pragmatic trials are designed to show the effectiveness of an intervention in the complex clinical setting of daily practice. But what makes a trial pragmatic? Can a clinical trial ever be completely pragmatic? Join us in this episode of Curbside Consults with Dr. David Harrington, statistical editor at the NEJM, as we discuss the elements...

The rise in popularity of e-cigarettes in the last 5 years has changed the landscape and language surrounding nicotine delivery, smoking cessation, and adolescent substance use. In this episode of Curbside Consults, Dr. Jonathan Winickoff, Professor of Pediatrics at Mass General Hospital for Children and Director of Pediatric Research...

Composite outcomes are frequently used as primary outcomes in randomized-controlled trials and observational studies. Why are they used? What are the limitations of their use? How are composite outcomes interpreted? Join us in this episode as Dr. David Harrington, statistical editor at the NEJM, helps breakdown composite outcomes.

Infective endocarditis is a rare infection associated with a high mortality. Patients are often admitted for prolonged periods of time to receive antibiotics. The Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis or the POET trial asked the question whether patients with left sided infective endocarditis can be switched to oral...

Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr David Harrington, our statistical editor here at the NEJM...

The number of medications available to treat diabetes continues to increase. Recently, there has been widespread interest in two classes of medications, the SGLT2 inhibitors and the GLP1 agonists. They have created quite the splash with improvements in cardiovascular outcomes in patients with type 2 diabetes. In this podcast...

Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr. David Harrington our statistical editor here...

Patients with cancer have a significantly higher risk of VTE. How do we assess risk for developing VTE in patients with cancer? Is there a role for primary VTE prophylaxis in cancer patients? If so what are our treatment options? On this podcast, our expert hematologist Dr Jean Connors delves into these questions and more.

Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, we discuss intention-to-treat and per-protocol...

Winter is upon us and asthma exacerbations are on the rise. But how well can clinicians and patients predict and prevent these asthma exacerbations before they start? NEJM Editor-in-Chief and Pulmonologist Dr. Jeff Drazen discusses the challenge clinicians and patients face in the setting of worsening asthma symptoms, also known as...

Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, we aim to cover basic ground over study...

Every medical resident will need to manage acute myocardial infarction at some stage. But what makes a patient with acute MI and cardiogenic shock more of a challenge to manage? NEJM Deputy Editor and Cardiologist Dr John Jarcho discusses the details around the pathophysiology and management in these patients and the recent paper...

There is a wide spectrum of disorders that affect the thyroid gland. Dr Hamnvik discusses the diagnostic testing of some of these common thyroid hormone disorders including hypothyroidism and hyperthyroidism and the evidence behind their management.

Atrial fibrillation is the most commonly encountered, clinically significant arrhythmia. Dr Eli Gelfand discusses the key issues of atrial fibrillation management and takes a deep dive into the complexities and evidence that informs the pillars of atrial fibrillation management: anticoagulation, rate and rhythm control.

Acute gastrointestinal bleeding is a broad topic with a range of manifestations, from scant hematochezia to the exsanguinating variceal hemorrhages. In this part 2 of 2 interviews, Dr. Navin Kumar discusses the management of variceal and lower GI bleeding and the evidence behind some of the major interventions...

Community-acquired pneumonia is one of the most commonly encountered infections in the hospital setting. In this interview, Dr. Anna Thorner discusses the basics of diagnosing and treating pneumonia as well as delving into the roles of procalcitonin and glucocorticoids...

Acute gastrointestinal bleeding is a broad topic with a range of manifestations, from scant hematochezia to the exsanguinating variceal hemorrhages. In this part 1 of 2 interviews, Dr. Navin Kumar discusses the management of acute non-variceal upper GI bleeding...

In this interview, Dr. Kathryn Hibbert reviews the biology underlying the effects of various fluids on the body and how sepsis disrupts the body’s natural response to corticosteroids. We also discuss the major points from these four new papers in the March 1, 2018 issue of NEJM and prior literature to get you up to speed on the evidence behind practice.

Listen to an interview with Dr. Patricia Kritek in which we go beyond the sound bites about low tidal-volume ventilation, the importance of PEEP, neuromuscular blockade and prone positioning to highlight the key clinical trials and discuss in detail how these therapies may work.