"Can't Be Done"

Join Adam Draper, founder of Boost VC and host of the "Can’t Be Done" Podcast, as he chats with Max Haot, CEO of Vast. Max shares his wild ride from Livestream founder to launching a space startup acquired by Vast. They explore his vision for humanity in space, from private stations to cosmic bathrooms. Expect deep insights, big dreams, and a lot of laughs in this inspiring, future-focused episode on tech, space, and what it all means for us.Max is an aerospace, consumer electronics, and internet entrepreneur. Founded, scaled, and successfully sold four companies including Launcher (acquired by Vast), Mevo (acquired by Logitech), and Livestream (acquired by IAC/Vimeo).Connect with Max HaotCompany website https://www.vastspace.com/Vast Space on LinkedIn https://www.linkedin.com/company/vastspace/Vast Space on Instagram https://www.instagram.com/vastspacestation/Vast Space on X https://x.com/vastMax on LinkedIn https://www.linkedin.com/in/maxhaot/Max on X https://x.com/maxhaot Connect with Boost VCBoost VC https://www.boost.vc/Boost VC on LinkedIn https://www.linkedin.com/company/boost-vc/?viewAsMember=trueBoost VC on X https://x.com/BoostVC?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5EauthorBoost VC on Instagram https://www.instagram.com/boost_vc/?hl=en

Join Adam Draper, founder of Boost VC and host of the "Can’t Be Done" Podcast, as he chats with James Sinka, Chief Scientific Officer at BIO Protocol. They dive into sci-fi novels, leadership, and the challenges Sinka faced on his journey. Beyond personal insights, they explore DeSci, the crucial role of scientists, and how researchers can secure financial rewards alongside recognition for groundbreaking work. Don’t miss this inspiring conversation on science, motivation, and innovation!Science Lead @ Bio.xyz - YCW19 Alum, repeat founder, and chemist. Connect with James SinkaBio Protocol https://www.bio.xyz/Bio Protocol on LinkedIn https://www.linkedin.com/company/bioprotocol/Bio Protocol on X https://x.com/bioprotocolJames on LinkedIn https://www.linkedin.com/in/jamessinka/James on X https://x.com/jamessinka Connect with Boost VCBoost VC https://www.boost.vc/Boost VC on LinkedIn https://www.linkedin.com/company/boost-vc/?viewAsMember=trueBoost VC on X https://x.com/BoostVC?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5EauthorBoost VC on Instagram https://www.instagram.com/boost_vc/?hl=en

Adam Draper, Founder of Boost VC and host of the "Can’t Be Done" Podcast, sits down with Andrew Bakst, Co-Founder of HairDAO, to explore how decentralized research is transforming hair loss treatments. They discuss HairDAO’s mission as an open-source R&D network, the role of crypto in reshaping technology, and why DAOs are redefining scientific funding. Plus, they dive into changing perceptions of hair loss and the flaws in traditional testing models."The answer to life is in your hair follicles.” - Douglas AdamsCo-founder/Chief Technocrat of HairDAO; MechE turned BioE; Stanford 2018. Connect with Andrew BakstHairDAO https://www.hairdao.xyz/HairDAO on LinkedIn https://www.linkedin.com/company/hairdao/HairDAO on Instagram https://www.instagram.com/hairdao/HairDAO on X https://x.com/HairDAO_?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5EauthorHairDAO on TikTok https://www.tiktok.com/@hairdao?lang=enAndrew on LinkedIn https://www.linkedin.com/in/andrew-bakst-78b21b100/Andrew on Instagram https://www.instagram.com/apballer4/?hl=enAndrew on X https://x.com/andrew_bakstAndrew on TikTok https://www.tiktok.com/@andrewbakst242?lang=en Connect with Boost VCBoost VC https://www.boost.vc/Boost VC on LinkedIn https://www.linkedin.com/company/boost-vc/?viewAsMember=trueBoost VC on X https://x.com/BoostVC?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5EauthorBoost VC on Instagram https://www.instagram.com/boost_vc/?hl=en

Join Adam Draper, Founder of Boost VC and host of the "Can’t Be Done" Podcast, as he chats with Patrick Joyce, Co-Founder of ResearchHub. They dive into the challenges of modern science, the DeSci movement, and how ResearchHub is transforming funding for researchers. Joyce shares insights on “shorting academia” and reimagining the scientific process. This conversation is a must-watch for anyone passionate about the future of research and innovation.Patrick is a former PhD and medical student who dropped out of two separate academic institutions because of the broken incentives that govern the global economy for scientific research. He cofounded ResearchHub to accelerate science by building a modern venue for the decentralized publication of scholarly literature that leverages cryptocurrency rewards to align incentives and increase knowledge creation. Connect with Patrick JoyceResearch Hub https://www.researchhub.com/Research Hub on LinkedIn https://www.linkedin.com/company/researchhubtechnologies/Research Hub on X https://x.com/ResearchHubPatrick on LinkedIn https://www.linkedin.com/in/patrick-joyce-396b953b/Patrick on X https://x.com/joycesticks Connect with Boost VCBoost VC https://www.boost.vc/Boost VC on LinkedIn https://www.linkedin.com/company/boost-vc/?viewAsMember=trueBoost VC on X https://x.com/BoostVC?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5EauthorBoost VC on Instagram https://www.instagram.com/boost_vc/?hl=en

Join Boost VC’s Adam Draper as he chats with Jordan Kutzer, founder of Throwback Studios, about how Jordan correlates the competitive nature of starting a company to baseball, especially regarding his mission to become the biggest VR brand and media company in the world. During this high velocity discussion, Jordan details the overcoming of multiple rejections, "coaching" customers, building visceral relationships in VR, and his inherent instinct to win. Tune in for key insights into the world of VR!Jordan holds a Stanford University B.A. in Science, Technology & Society with a concentration in Information Technology, Media and Society (2015). Former Stanford Student-Athlete and Pitcher. Working to empower the next generation of game creators. Connect with Jordan KutzerThrowback Studios https://throwback.studio/Throwback Studios on LinkedIn https://www.linkedin.com/company/throwbackvr/Throwback Studios on Instagram https://www.instagram.com/throwback.vr/Throwback Studios on X https://x.com/throwbackvrThrowback Studios on TikTok https://www.tiktok.com/@throwbackvr Jordan on LinkedIn https://www.linkedin.com/in/jordankutzer/Jordan on Instagram https://www.instagram.com/jordankutzer/?hl=enJordan on X https://x.com/jordankutzer Jordan on TikTok https://www.tiktok.com/@jordankutzer Connect with Boost VCBoost VC LinkTree https://linktr.ee/boostvc

Join Boost VC’s Adam Draper as he chats with Sampriti Bhattacharyya, founder of Navier. She shares her journey from a small city in India to building a next-gen maritime company in the U.S. From sun-tracking solar panels to dodging marriage and surviving a landslide, Sampriti’s story is one of overcoming challenges. She highlights the value of exceptional people, persistence through failures, and her mission to transform the future of waterways. Tune in for an inspiring episode!Sampriti is a 3x founder and the CEO of Navier, a pioneering company at the forefront of innovation in sustainable, maritime transportation. Sampriti's journey began with a PhD from Massachusetts Institute of Technology (MIT) after completing projects with NASA. Her academic pursuits span diverse fields including Electrical Engineering, High Energy Physics, Aerospace Engineering, MechE/Robotics/Control & AI. Driven by a passion for tackling fundamental technological challenges with global implications, Sampriti thrives on creating products that push the boundaries of exploration and discovery. Her work reflects a deep-seated commitment to leveraging cutting-edge technology to address pressing societal needs and unlock new frontiers of possibility.Connect with Sampriti BhattacharyyaNavier https://www.navierboat.com/Navier on LinkedIn https://www.linkedin.com/company/navierboat/Navier on Instagram https://www.instagram.com/navierboat/?hl=enNavier on X https://x.com/navierboatSampriti on LinkedIn https://www.linkedin.com/in/sampriti-bhattacharyya-40368a3/Sampriti on Instagram https://www.instagram.com/sampriti_bh/?hl=enSampriti on X https://x.com/sampritibh?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor Connect with Boost VCBoost VC LinkTree https://linktr.ee/boostvc

Join Boost VC’s Adam Draper as he chats with AJ Forsythe, founder of Coop, about his not-so-illustrious journey as a founder, and the rewarding yet challenging components of building companies. Discover how AJ’s journey evolved from his first steps building iCracked to his ambitious mission of putting chickens on Mars. Adam and AJ reflect on the nature of entrepreneurship and the importance of seizing life's fleeting moments. Tune in for another fun episode filled with shark diving, fossils, and more! AJ is going to put chickens on mars. He’s a serial entrepreneur and absolutely loves the startup life (mainly because he’s probably unemployable 😂). In college he founded YC-backed iCracked which was a multinational on-demand phone repair and insurance company that grew to 6 countries and a few thousand technicians. They were acquired by Allstate in 2019 and now he’s running Boost VC backed company, Coop, which builds AI powered chicken coops for anyone’s backyard. AJ has been recognized on Forbes' 30 Under 30 list , was #23 on INC 5000, and continues to innovate at the intersection of agriculture and tech – and wakes up with a smile everyday because he’s building his dream company. Connect with AJ ForsytheCoop https://smart.coop.farm/Coop on LinkedIn https://www.linkedin.com/company/coop-inc/Coop on Instagram https://www.instagram.com/thesmartcoop/Coop on TikTok https://www.tiktok.com/@thesmartcoopCoop on X https://x.com/thesmartcoopAJ on LinkedIn https://www.linkedin.com/in/ajforsythe/AJ on Instagram https://www.instagram.com/aj__forsythe/AJ on X https://x.com/spudzeee Connect with Boost VCBoost VC LinkTree https://linktr.ee/boostvc

Join Boost VC’s Adam Draper as he chats with Collin West, founder of Ensemble VC, about his incredible journey rowing across the Arctic Ocean and how it changed his approach to decision-making and team management. Learn how this experience influences Ensemble’s data-driven approach to assessing startups. Adam and Collin dive into the evolution of venture capital and reflect on their near-death experiences. Tune in for laughs, insights, and a fresh perspective on adventure and opportunity in VC! Collin is the Founder and Managing Partner of Ensemble VC, which focuses on using data to identify top teams building companies that can impact a billion people. Collin is also a Guinness World Record holder for leading the first-ever crossing of the Arctic Ocean. His team of four rowed non-stop and unsupported for 41 days through the biggest storm season in Arctic history - this is where he learned just how important a great team is pursuing a mission that's never been done before. Collin's prior investments include Zoom Video (NASDAQ: ZM), Carta, Groww, ICON, Saronic, Sidecar Health, and many others. Previously, Collin was a founder of the Kauffman Fellows VC fund and on the founding fund team at the pioneering data-driven VC firm Correlation Ventures. An avid competitor, Collin spends his free time training Brazilian jiu-jitsu, mountain biking, and climbing mountains.Connect with Collin WestEnsemble VC https://www.ensemble.vc/home/#ensemble Ensemble VC on LinkedIn https://www.linkedin.com/company/ensemblevc/Collin on LinkedIn https://www.linkedin.com/in/collinwest/Collin on Instagram https://www.instagram.com/collinrwest/?hl=en Connect with Boost VCBoost VC LinkTree https://linktr.ee/boostvc

According to a BCG report, only 19% of VCs have some kind of scientific or technological competence. And that creates a translation problem between deep tech founders and investors. To close that gap, Arkady Kulik and his cofounder, Tamaz Khunjua, built RPV, a venture fund that brings scientific expertise to the market and helps scientists become strong entrepreneurs. On this episode of The Boost VC Podcast, Arkady joins us to explain how the RPV team’s extensive background in science and entrepreneurship serves deep tech startups. Arkady describes how starting a venture fund differs from founding other companies and shares his excitement around ‘being at the edge of science’ as a frontier tech VC. Listen in for Arkady’s unique take on what it means to be useful to others and learn how RPV is working to make talented scientists billionaires! Topics Covered The idea behind RPVHelp scientists become strong entrepreneurs‘Commercialization of science’ How Arkady got into venture capitalMoved to US to be part of scientific exploration of humanityLack of funding in prototyping stage of deep tech startups Arkady’s biggest accomplishment before age 20Launched first company at 18 without external investmentScaled to annual revenue of $5M in third year How starting a venture fund differs from starting other companiesMore competitive, thousands of similar funds raising moneyHarer to differentiate and properly tell story of niche What part of being a VC Arkady enjoys the mostBeing at edge of science and meeting interesting peopleFinding processes that make things work The secret skills Arkady is most proud ofDeveloped extreme level of disciplineExtremely organized in managing time and data How Arkady thinks about being useful to othersProvide with relevant information or connectionsPut smile on someone’s face, make life better The most valuable thing RPV provides for deep tech startupsExternal proof point for science and technologyEntrepreneurial experience and change management Arkady’s ‘deathbed test’ to measure successNothing ‘could have but didn’t achieve’Self-actualization (happy, complex person) Connect with Arkady Kulik RPV https://rpv.global/RPV on LinkedIn https://www.linkedin.com/company/rpvglobal/Arkady on LinkedIn https://www.linkedin.com/in/arkady-kulik/Arkady on X https://twitter.com/arkadykulik Resources Starburst Aerospace https://starburst.aero/Cantos VC https://cantos.vc/Countdown https://countdown.capital/Fifty Years https://fiftyyears.com/Productivity Planner https://www.intelligentchange.com/products/productivity-plannerTerraforming Mars https://www.fryxgames.se/games/terraforming-mars/Breakfast with Pops: A Venture Capital Handbook by Adam Draper and William H. Draper III https://www.amazon.com/Breakfast-Pops-Venture-Capital-Handbook/dp/B0C1JHXTQF Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on X https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

If a VC is excited about a deep tech company upfront, what can we do to temper our enthusiasm and make a rational decision on whether to invest? Maryanna Saenko is Cofounder and Partner at Future Ventures, an early-stage VC firm that focuses on mission-driven companies at the cutting edge of disruptive technology. Future Ventures looks to back visionaries who push the boundaries of possibility. Some of their recent investments include Beeflow, Deep Genomics and Earthshot Labs. On this episode of Boost VC, Maryanna joins us to share her definition of deep tech, describing how Future Ventures looks for opportunities ‘unlike anything we’ve ever seen before.’ Maryanna offers her take on why the two-person structure of a venture firm is ideal and discusses some of the deep tech deals she wishes she’d been closer to. Listen in for Maryanna’s insight on building organizations around big shifts in science or technology and learn her process for dialing down the excitement after a pitch to decide whether her YES will hold. Topics Covered Maryanna’s biggest accomplishments before age 20Recognized she wouldn’t survive public high schoolGot into Hopkins prep school on scholarship How Maryanna got into venture capitalWorked for early-stage company out of collegeJob offer from Daimler to figure out driverless carsIntroduced to head of innovation lab at Airbus The most important lessons Maryanna has learned as a VCTrust your intuitionDon’t waste time justifying a startup’s relevance How Maryanna defines deep tech‘Unlike anything we’ve ever seen before’Index on novelty at Future Ventures What Maryanna does when she’s all-in on a company right awayAsks what she must believe about reality for YES to holdDiscussion with partner to temper her excitement Why Maryanna prefers the two-person structure in ventureIdeal for its efficiency and intellectual honestyNever puts someone in tie-breaker position Maryanna’s superpowers as a venture investorConfident in ability to assess tech on first principlesKnow how to build orgs around shifts in science or tech What deals Maryanna wishes she had been closer toStructure of open AIDeep seabed mining, recycling battery technology Maryanna’s definition of successFeel landscape of possibility was totally exhausted‘Everything I could give to this, I did’ Connect with Maryanna Saenko Future Ventures https://future.ventures/ Future on Facebook https://www.facebook.com/FutureVenturesVCFuture on Instagram https://www.instagram.com/future.ventures/Future on LinkedIn https://www.linkedin.com/company/futureventures/Maryanna on LinkedIn https://www.linkedin.com/in/maryannasaenko/Maryanna on Twitter https://twitter.com/FutureSaenko Resources Lux Research https://www.luxresearchinc.com/DARPA Grand Challenge https://www.darpa.mil/about-us/timeline/-grand-challenge-for-autonomous-vehiclesAirbus BizLab https://www.airbus.com/en/innovation/innovation-ecosystem/airbus-bizlabBeeflow https://www.beeflow.com/Decoding the World by Po Bronson and Arvind Gupta https://www.amazon.com/Decoding-World-Questioner-Po-Bronson/dp/1538734311Redwood Materials https://www.redwoodmaterials.com/American Prometheus: The Triumph and Tragedy of J. Robert Oppenheimer by Kai Bird and Martin J. Sherwin https://www.amazon.com/American-Prometheus-audiobook/dp/B000OZ0J0W/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

Deep tech founders are either technically gifted or great at building a business. But it's seldom both, at least in the beginning. So, what should venture investors pay attention to when we’re choosing founders in these disruptive technologies? Greg Castle is Founder and Managing Director at Anorak Ventures, a firm that invests in early-stage deep tech startups. An entrepreneur and corporate marketer turned VC, Greg has invested in 120 companies, including Oculus, Flexport and Mux. On this episode of Boost VC, Greg joins us to explore how his view of venture investing has changed since he wrote his first check, explaining what he looks for in a founder and how he evaluates deep tech startups differently. Greg shares his mixed feelings about the VR market right now and how he benefits from having a partner to engage in conviction-based decision-making. Listen in for Greg’s advice on where to deploy capital in deep tech and learn how Anorak chooses founders who apply disruptive technologies to business problems in any industry. Topics Covered How Greg got into venture capitalCurious person who advocates for people he believes inGot lucky in first few personal investments, e.g.: Oculus The most important lessons Greg has learned as a VCWhat high-functioning teams and companies look likeNot to take it personally when things don’t go as planned What Greg pays attention to when he’s choosing foundersHow they interact with cofounders, react to feedbackPunctuality at meetings, preparedness and responsiveness The questions Greg asks himself before he invests in a startupDo I believe in the founder?Do I believe in the market? How Greg evaluates deep tech companies differentlyMove forward with presumption that anything’s possibleConsider if technically gifted person can build business Greg’s mixed feelings about the VR market right nowViable platform where developers make real moneyFrustrated by lack of competition, Meta fumbling the ball Greg’s thoughts on Apple entering the VR/AR market‘Nobody can make a product cool like Apple can’Not well-positioned in immersive gaming (primary use case) The Anorak investment thesisHandful of technologies will have outsized impact on futureFind teams leveraging those technologies, industry agnostic Greg’s advice on where to deploy capital in deep techAlways comes down to peopleBuild out ecosystem of investors, founders How Greg thinks about scale in venture investingFind great people in areas that are not your strengthsScale of funds = $15M to $25M per partner How Greg benefits from taking on a partnerNeed to explain yourself to thought partnerCan still move quickly when he needs to Greg’s biggest accomplishments before age 20Building group of friends in collegeStill works with many of them Greg’s definition of successConfident and comfortable in your own skinContent with what you have Connect with Greg Castle Anorak Ventures https://www.anorak.vc/Anorak on Medium https://anorakvc.medium.com/Anorak on Twitter https://twitter.com/AnorakVenturesAnorak on LinkedIn https://www.linkedin.com/company/anorak-ventures/Greg on LinkedIn https://www.linkedin.com/in/gregorycastle/Greg on Twitter https://twitter.com/gpcastle12 Resources Greg Castle on Boost VC EP001 https://www.youtube.com/watch?v=2PyO3LpZD9QGreg Castle on Boost VC EP089 https://open.spotify.com/episode/6qYRcDMoemjrMHDxKONu4AOculus https://www.meta.com/quest/GOLF+ https://www.golfplusvr.com/FitXR https://fitxr.com/Neverwhere by Neil Gaiman https://www.amazon.com/Neverwhere-Novel-Neil-Gaiman-ebook/dp/B000FC130ESnow Crash by Neal Stephenson https://www.amazon.com/Snow-Crash-Novel-Neal-Stephenson-ebook/dp/B000FBJCJE/Hyperion by Dan Simmons https://www.amazon.com/Hyperion-Cantos-Book-1-ebook/dp/B004G60EHS/Neuromancer by William Gibson https://www.amazon.com/Neuromancer-Sprawl-Trilogy-William-Gibson-ebook/dp/B000O76ON6/ Breakfast with Pops: A Venture Capital Handbook by Adam Draper & William Henry Draper, III https://www.amazon.com/Breakfast-Pops-Venture-Capital-Handbook/dp/B0C1JHXTQF‘Perception Is Reality’ Presentation https://www.anorak.vc/post/perception-is-reality-8-startup-marketing-principles Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

How does a venture firm approach investments in deep technology? Seth Winterroth is Partner at Eclipse Ventures, a VC firm that partners with exceptional entrepreneurs to build companies that redefine physical industries. Seth has nine years of experience in venture capital, serving as Associate at GE Ventures before he joined the team at Eclipse. On this episode of Boost VC, Seth joins us to explore how Eclipse thinks about investing in emerging technologies, explaining how the team engages with customers and leverages internal expertise to identify high-magnitude market opportunities. Seth shares his interest in robotics, discussing why the acquisition of Kiva Systems sparked his interest in this particular deep tech field and how he identified the opportunity to invest in 6 River Systems—the first deal he led at Eclipse. Listen in for Seth’s advice to young VCs on cultivating patience and responding to chaos with calm, engaging with founders in a way that’s rational and devoid of fear. Topics Covered The thesis at Eclipse VenturesSmall teams of engineers solving hard development problemsIndustries that operate in physical world (80% of global GDP) How Seth thinks about investing in emerging technologyStart with markets, customer pain pointsFind specialist to develop n-of-1 solutionAdd traditional engineers with experience scaling technology What gets Seth excited about roboticsKiva Systems acquisition by Amazon sparked interestSaw market trends driving adoption of autonomous systems The success of Seth’s first investment at Eclipse, 6 River SystemsRobotics company in supply chain logisticsAcquired for $500M by Shopify in 2019 How Seth identified the opportunity to invest in 6 River SystemsIdeal team profile and product differentiationGap in market to replace Kiva Systems Eclipse’s institutional process of thesis developmentEngage with customers, purchasing decision-makersInternal engineering expertise to identify gaps Eclipse’s internal venture equity programCases where did research but didn’t find right opportunity Engineer storm vs. wait for lightning to strike What Eclipse does to win dealsBuild relationships with foundersProvide evidence of value-added capital The part of a deal Seth is most excited aboutFind high-magnitude market opportunity to match worldviewGo to partners with conviction and say THIS ONE What Seth would tell his 25-year-old selfBe patient, don’t rush to have track record in ventureRespond to chaos with calm, be rational and devoid of fear What differentiates Eclipse from other venture firmsTackle category of economy traditional VCs shy away fromDeep involvement with companies to improve odds Seth’s biggest accomplishments before age 20Live on own and travel worldSpend meaningful time with and learn from grandfather Connect with Seth Winterroth Eclipse Ventures https://eclipse.vc/Eclipse on LinkedIn https://www.linkedin.com/company/eclipse-vc/Eclipse on Twitter https://twitter.com/eclipseventures Seth on Twitter https://twitter.com/SethwinterrothSeth on LinkedIn https://www.linkedin.com/in/sethwinterroth/ Resources Kiva Systems Acquisition https://techcrunch.com/2012/03/19/amazon-acquires-online-fulfillment-company-kiva-systems-for-775-million-in-cash/Willow Garage https://www.businessinsider.com/a-look-back-at-willow-garage-2016-2DARPA Grand Challenge https://www.darpa.mil/about-us/timeline/-grand-challenge-for-autonomous-vehicles6 River Systems https://6river.com/Bright Machines https://www.brightmachines.com/BrightInsight https://brightinsight.com/Foxglove Studio https://foxglove.dev/Kevin Kelly’s Blog ‘You Are Not Late’ https://medium.com/message/you-are-not-late-b3d76f963142Richard Hamming’s Talk ‘You and Your Research’ https://www.youtube.com/watch?v=a1zDuOPkMSwTeam of Rivals: The Political Genius of Abraham Lincoln by Doris Kearns Goodwin https://www.amazon.com/Team-Rivals-Political-Abraham-Lincoln/dp/0743270754Lincoln https://www.imdb.com/title/tt0443272/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

What inspires a venture firm to focus on deep tech? Ian Rountree is Founder and General Partner at Cantos, a venture fund that invests in potentially world-changing deep tech startups. Cantos focuses on hardware and bio investing at the intersection of climate and industrials, life sciences and AI, aerospace and defense, and next-generation computing. On this episode of Boost VC, Ian joins us to share his definition of deep tech and explain why he underwrites technical risk rather than market risk. Ian discusses the value of founder empathy, challenging VCs to see the entrepreneur as their customer and LPs as shareholders in the portfolio. Listen in to understand what drives Ian to make a global-scale impact, backing founders who tackle climate change, disease, armed conflict, poverty and existential risk. Topics Covered Ian’s biggest accomplishment before age 20Getting Vanderbilt to accept him off waitlist Refused to take NO as answer Ian’s take on who is the customer in venture capitalFounder = customerLP = shareholder What inspired Ian to focus on deep techTackle big problems, e.g.: climate change, povertyDeep tech startups outperformed rest of portfolio How losing his father early informs Ian’s workFeels hard deadline to career and lifeWants to play small role in changing world The criteria Ian uses to decide if a startup is ‘important’Nonzero chance of global-scale impactTackles climate, disease, armed conflict or poverty How Ian defines deep techTaking technical risk rather than market riskCantos specializes in hardware and bio investing How Ian thinks about growing the Cantos organizationFrom solo GP to 4 equal partners‘Fire’ himself by age 55 What’s behind Benchmark’s equal partnership structureSet up for generational turnover from jumpMay also be consequence of early success Why a deep tech VC doesn’t need to be technicalAsk expert if violation of physics involvedStartups that change world challenge status quo What differentiates software investing from deep techSoftware involves market risk, easy to pivotDeep tech involves technical risk, hard to pivot Ian’s diligence criteriaSize of market, potential margins at scaleFounder who understands their WHY Connect with Ian Rountree Cantos https://cantos.vc/Cantos on Twitter https://twitter.com/cantosIan on Twitter https://twitter.com/ianrountreeIan on LinkedIn https://www.linkedin.com/in/ianrountree/Near Frontier Podcast https://nearfrontier.castos.com/ Resources Fred Wilson’s Blog ‘The VC’s Customer’ https://avc.com/2005/11/the_vcs_custome/Fred Wilson’s Blog ‘The VC’s Customer (Continued)’ https://avc.com/2009/07/the-vcs-customer-continued/Radiant https://www.radiantnuclear.com/Tim Urban’s TED Talk on Procrastination https://www.ted.com/talks/tim_urban_inside_the_mind_of_a_master_procrastinator/cBenchmark https://www.benchmark.com/eBoys: The First Inside Account of Venture Capitalists at Work by Randall E. Stross https://www.amazon.com/eBoys-Inside-Account-Venture-Capitalists/dp/0812930959Benchmark Part I on the Acquired Podcast https://www.acquired.fm/episodes/benchmark-capitalBenchmark Part II on the Acquired Podcast https://www.acquired.fm/episodes/benchmark-part-ii-the-dinnerUnion Square Ventures https://www.usv.com/Cerebras https://www.cerebras.net/Eric Vishria on Twitter https://twitter.com/ericvishria Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

Many independently minded, young scientists are too ambitious for academia… But the startup world isn’t quite right for them either. How might decentralized science provide a space for these innovators to do their work? Niklas Rindtorff is the classical scientist behind LabDAO, an online home for inventors that builds open tools for scientific research. Niklas coauthored his first paper before the age of 20, and he has expertise in CRISPR and cancer research. On this episode of Boost VC, Niklas joins us to explain how classical science emerged after World War II and explore the problems with the NIH grant funding process. Niklas shares his open-access approach to consuming scientific media and describes how DeSci is experimenting with different ways to measures the importance of new science. Listen in to understand how decentralized science can serve as the bridge between research organizations and science startups, building an ecosystem for inventors who don’t fit into the nonprofit or for-profit world. Topics Covered How Niklas defines scienceFormal knowledge generation processFishing at edge of what is known How World War II changed the way we do scienceConflict won because of US sophisticated techNIH funding created class of full-time scientistsSystem doesn’t always maximize progress How the importance of new science is determinedMeasured by citations vs. marketsDeSci experiments with different accounting How Niklas consumes scientific mediaUsed to use few free, open-access journalsNow leverage Twitter bookmarks, preprints What LabDAO does for scientistsProvide tools to work wherever they areCurrent focus on computational biology What inspired Niklas to build LabDAOExperience with inventions stuck in bureaucracyMeasure number of patients treated vs. citations The age distribution of NIH grant recipientsAges with scientists who were firstNo market discipline, don’t answer to public How we might equalize the demographic of NIH winnersCreate more NIHsPrivate funding agency with philanthropic match How we might invest in a portfolio of scienceCharge higher fee to run research-oriented fundOnline collectives do research sponsorships How LabDAO itself is fundedNonprofit governed by tokenPrivate investors buy token for stake on projects The relationship between academia and DeSciConnective tissue among existing organizationsInventors who don’t fit in academia or startups Niklas’ definition of successStrive toward personal valuesInvent cool stuff Connect with Niklas RIndtorff LabDAO https://www.labdao.xyz/LabDAO on Discord https://discord.com/invite/labdaoLabDAO on GitHub https://github.com/labdaoLabDAO on Snapshot https://snapshot.org/#/labdao.ethLabDAO on Medium https://medium.com/@labdaoLabDAO on Twitter https://twitter.com/lab_daoNiklas on Twitter https://twitter.com/niklas_tr Resources Broad Institute https://www.broadinstitute.org/‘Science the Endless Frontier’ 1945 Report to Congress https://www.nsf.gov/od/lpa/nsf50/vbush1945.htmNational Institutes of Health https://www.nih.gov/Public Library of Science https://plos.org/bioRxiv https://www.biorxiv.org/New Science https://newscience.org/VitaDAO https://www.vitadao.com/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

In academia, most scientists publish their ideas and stop there. But if we want our breakthroughs to benefit society, we have to take it a step further. So, what does it look like to commercialize scientific research? What mindset do academics need to work at the intersection of science and industry? Ben Lamm has a career of building successful deep tech businesses, and George Church has a career of commercializing academic science. Together, they are the cofounders of Colossal, a breakthrough bioscience and genetic engineering company that is pioneering animal de-extinction technology to restore lost ecosystems for a healthier planet. On this episode of Boost VC, Ben and George join us to explain how bringing back the woolly mammoth addresses climate change and explore their approach to the ethical concerns around de-extinction. They discuss the benefits of Colossal technology beyond Arctic rewilding, describing how their work helps endangered animals and promotes conservation. Listen in for Ben and George’s insight on commercializing science and learn how to get comfortable enough with risk to turn academic ideas into industry. Topics Covered How George defines sciencePredict and create new options for humanityGoal to build better world Why Ben & George are bringing back the woolly mammothRestore previous ratio of grass to treesSequester carbon at rate only possible in Arctic How Ben & George approach the ethical concerns re: de-extinctionBelieve in radical transparencyLearn from negative feedback, people who question Why George works at the intersection of academia and industryLikes to work with curious young peopleExposure to diversity of ideas Why Colossal needs government collaboration and supportSeveral governments, Indigenous groups in ArcticClimate change, biodiversity and species preservation How woolly mammoths promote carbon removalKnock down trees so more grass can growCold, Arctic grasslands sequester carbon particularly well The benefits of Colossal technology beyond Arctic rewildingEradicate EHV virus in elephantsPromote species conservation How Ben & George think about commercializing scienceGo beyond publication to help societyFeedback from investors and academia What makes Ben & George’s partnership workGeorge’s lab provides idea from academic studyBen figures out product-market fit and funding George’s advice to academics on commercializing productsCan’t be afraid of failureCan come back from bankruptcy How Ben & George think about taking big risksBen believed grandmother saying he could do anythingAcademic failures taught George he would survive The impact Ben & George hope to make with ColossalEx utero development, species preservationThousands of Arctic elephants to sequester carbonAdvancements in reading and writing of genomes How Ben & George define successBenefit society, facilitate survival of speciesCreate things that are additive Connect with George Church & Ben Lamm Colossal https://colossal.comColossal on Twitter https://twitter.com/ItIsColossalColossal on Facebook https://www.facebook.com/itiscolossal/Colossal on Instagram https://www.instagram.com/itiscolossal/George on Twitter https://twitter.com/geochurchBen on Twitter https://twitter.com/federallamm Resources Citizen Science https://www.citizenscience.gov/#Personal Genome Project https://www.personalgenomes.org/How to Grow (Almost) Anything https://www.media.mit.edu/courses/htgaa/DIYbio https://diybio.org/Church Lab https://arep.med.harvard.edu/Hypergiant https://www.hypergiant.com/Pleistocene Park https://pleistocenepark.ru/Chris Mason Author Talk https://mitpress.mit.edu/blog/author-talk-the-next-500-years-by-christopher-e-mason/Prehistoric Planet https://tv.apple.com/us/show/prehistoric-planet/umc.cmc.4lh4bmztauvkooqz400akxav Connect with Boost VCBoost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

Why invest in decentralized science? James Sinka is a classically trained chemist and materials engineer and DeSci investor at Orange DAO, a fund for crypto projects supported by an alliance of Y Combinator alumni. On this episode of Boost VC, James joins us to discuss where he sees opportunities in DeSci, describing the benefit of publishing null results and how open science helps us get to the truth more quickly. James explains how the Orange Fund and Orange DAO work together to finance crypto projects and shares his advice to scientist-founders on generating your own luck through action. Listen in for James’ insight on the first use cases for decentralized science and learn how investing in DeSci can democratize access to research and help rebel scientist-entrepreneurs ship products in the real world! Topics Covered How James defines scienceProcess to uncover truths about worldNot an institution of truth What attracted James to DeSciBenefits of publishing null resultsLess wasted science effort and money How James got into cryptoExposed to Bitcoin in collegeOffers financial freedom to bet on self How Orange DAO works$50M fund for crypto projectsY Combinator alum support efforts James’ advice for foundersBias toward actionBe willing to be wrong Where James sees opportunity in DeSciFree flowing access to informationGet to truth more quickly What’s wrong with academic science nowResearch for prestige, not passionValue determined by citation numbers How the Alzheimer’s fraud happenedConflict of interest at NIHNo reverse accountability system What inspires James to invest in DeSciPush boundaries of scientific researchHelp scientists build real products James’ take on the first use case for DeSciData warehousing (null results)New forms of publication open to all James’ definition of successTime, space and resourcesAbility to do what you love Connect with James Sinka Orange DAO https://www.orangedao.xyz/Orange DAO on Discord https://discord.com/invite/DVncb7UxGBOrange DAO on Snapshot https://snapshot.org/#/orangedaoxyz.ethOrange DAO on Etherscan https://etherscan.io/token/0x1bBD79f1Ecb3f2cCC586A5E3A26eE1d1D2E1991fOrange DAO on OpenSea https://opensea.io/collection/alumni-gemsOrange DAO on Twitter https://twitter.com/OrangeDAOxyzJames on Twitter https://twitter.com/jamessinka Resources Through the Wormhole https://www.imdb.com/title/tt1513168/Y Combinator https://www.ycombinator.com/NEAR Protocol https://near.org/Algorand https://www.algorand.com/Blockchain Capital https://blockchain.capital/The Memo by Howard Marks https://link.chtbl.com/thememobyhowardmarksMulticoin Capital https://multicoin.capital/Solana https://solana.com/Exploring Decentralized Science with Balaji Srinivasan https://www.youtube.com/watch?v=xrcRI_hYDtQNaval https://nav.al/Brian Armstrong https://twitter.com/brian_armstrongEpsilon3 https://www.epsilon3.io/Benchling https://www.benchling.com/Amplitude https://amplitude.com/Sci-Hub https://sci-hub.se/Patrick Joyce on the Boost VC Podcast https://www.boost.vc/bvc/2022/08/04/desci-ep-2-addressing-the-misalignment-of-incentives-in-science DeSci Labs https://desci.com/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

Under the current centralized system, drug development happens in silos. Pharmaceutical companies don’t share information. Scientists run the same failed experiments over and over again. And the process of bringing a drug to market typically takes ten-plus years. But Paul Kohlhaas and Tyler Golato are building a new way to do drug development. A system that allows for collaboration and dramatically increases the speed of breakthroughs in healthcare. CEO Paul and CSO Tyler are the Cofounders of Molecule, a decentralized biotech protocol that establishes a Web3 marketplace for research-related intellectual property. On this episode of Boost VC, Paul and Tyler join us to explain how their personal experiences with the failures of healthcare inspired their interest in changing the system. They discuss Molecule's end-to-end ecosystem for bringing drugs to market, describing how their IP-NFT both protects innovation and makes it more open, sharable and collaborative. Listen in for insight on Eroom's Law and learn how open science leads to enormous efficiency gains in the drug development process. Topics Covered How Paul & Tyler define scienceEmpirical discovery of knowledgeProgressive search for truth What inspired Paul & Tyler’s interest in sciencePersonal experience with failures of healthcarePotential for DeSci to foster new behaviors Paul & Tyler’s failed experiment with crowdfundingTried to raise money for microdosing studyPartnership with University of Toronto How Molecule has evolved since 2019Ecosystem for bringing drugs to marketIP-NFT framework for collaboration How to make scientists more open to sharingImprove user experienceStreamline funding process The power of Molecule’s IP-NFT frameworkIntellectual property rights held on chainCollectively owned by patients The value prop for open scienceCreates enormous efficiency gainsMakes drug development much cheaper Jack Scannel’s naming of Eroom’s LawTechnology to discover drugs improvingYet drug discovery output in decline The goals for DeSci over the next decadeExtend quality of human health spanMake science self-sovereign, self-aware How Paul & Tyler define successRemain true to values and vision for lifeNet positive impact on every person Connect with Paul Kohlhaas & Tyler Golato Molecule https://www.molecule.to/Molecule on GitHub https://github.com/moleculeprotocolMolecule on Discord https://discord.com/invite/uAGW7K4hQUMolecule on YouTube https://www.youtube.com/channel/UCWYW5ho3L_d0EO_a619E7RQMolecule on LinkedIn https://www.linkedin.com/company/molecule-protocol Molecule on Twitter https://twitter.com/molecule_daoPaul on Twitter https://twitter.com/paulkhlsTyler on Twitter https://twitter.com/GolatoTyler Resources Linum Labs https://www.linumlabs.com/Molecule’s Crowdfunding Experiment with the University of Toronto https://www.molecule.to/blog/psychedelics-on-the-blockchainNIH Grants and Funding https://www.nih.gov/grants-fundingSimon de la Rouviere on Bonding Curves https://www.youtube.com/watch?v=-k4M6QAW2pMJack Scannell on Eroom’s Law https://refoundable.com/research/life-after-erooms-law-interview-with-jack-scannell.htmlMeme Lordz https://memelordz.io/North American Association of Technology Transfer http://aim.autm.net/Ray Kurzweil https://www.kurzweilai.net/Peter Diamandis https://www.diamandis.com/Abundance 360 https://www.abundance360.com/summit Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

The internet has given content creators of all kinds a way to monetize their talents. Writers have Medium. Teachers and vloggers have YouTube. But scientists don’t have a platform to earn money for their research. That’s why Dr. Jocelynn Pearl calls scientists the ‘unappreciated creator class.’ And that’s why she’s working to further the DeSci movement, leveraging Web3 technology to enable breakthrough research through better incentives. A molecular and cellular biologist by training, Jocelynn serves as cofounder of LabDAO, a design marketplace for life science research, and host of The UltraRare Podcast, a show about the builders behind the decentralized science movement. On this episode of Boost VC, Jocelynn joins us to explain how DeSci solves for speed of translation and communicates science better than existing systems, exploring how the movement might specifically facilitate breakthroughs around rare disease. Jocelynn discusses how academia owns the best scientific minds without rewarding them appropriately and describes how DAOs offer alternatives to classic academic publishing and drug development. Listen in as Jocelynn makes the case that scientists are the unappreciated creator class and learn how access to the right advisors and capital can accelerate the decentralized science movement. Topics Covered How Jocelynn defines scienceProcess of exploring unanswered questionsConversation among people trained to be critical How Jocelynn defines decentralized scienceWay of democratizing resourcesCommunicate science better than existing systems What inspired Jocelynn’s interest in DeSciCentralization of research inhibits progressSolve for speed of translation, cost reduction How DeSci might facilitate breakthroughs in rare diseaseExplore drug development through DAOsCommunication of collective knowledge Leveraging DeSci to incentivize scientific researchChange academic publishing through tokenizationAllow patient group to co-own drug development Why Jocelynn sees scientists as the unappreciated creator classWriters have Medium, vloggers have YouTubeNo platform for scientists to monetize content What needs to change for scientists to be appreciated creatorsActivists like Seemay Chou who encourage sharingAlternative model to academic publishing How academia owns the best minds (without rewarding them)Earn $30K/year working full-time in PhD programDoes form you as scientist and provides network How CROs address the lab space shortageStands for contract research organizationFarm out research can’t perform in-house The challenges of establishing decentralized scienceTraditional academia and publishing will fight backMuch work required to override existing system What's stopping the DeSci space from accelerating fasterStruggles to bring in advising and capitalWorking on projects outside day jobs Jocelynn’s definition of success Lasting change in scientific ecosystemPivot how progress happens Connect with Jocelynn Pearl Jocelynn’s Website https://www.jocelynnpearl.com/LabDAO https://www.labdao.xyz/LabDAO on Twitter https://twitter.com/lab_daoLabDAO on GitHub https://github.com/labdao LabDAO on Discord https://discord.com/invite/labdaoUltraRare Podcast https://rss.com/podcasts/ultrarare/ Resources A Guide to Decentralized Biotech https://future.com/a-guide-to-decentralized-biotech/The DeSci Wiki https://www.jocelynnpearl.com/Molecule Protocol https://www.molecule.to/Ben Hills https://twitter.com/0xboodleVibe Bio https://www.vibebio.com/Experiment.com https://experiment.com/Arcadia Science https://www.arcadia.science/Invisible College https://www.invisiblecollege.xyz/Charles River Laboratories https://www.criver.com/Cameron & Tyler Winklevoss on Boost VC EP102 https://podbay.fm/p/the-boost-vc-podcast/e/1606903200Manhattan Project https://www.history.com/topics/world-war-ii/the-manhattan-projectThiel Fellowship http://www.thielfellowship.org/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

Only 1% of first year PhD students become research professors. This creates a hypercompetitive environment where scientists will do whatever it takes to get funding, even if that means tweaking statistical analyses to make their findings seem more significant. But decentralized science is working to address this egregious misalignment of incentives and reward science done the right way. Patrick Joyce is the Cofounder and COO of ResearchHub, a Reddit-style forum that allows anyone to share, discuss and curate scientific papers—and earn ERC-20 tokens for doing so. On this episode of Boost VC, Patrick joins us to discuss the misalignment of incentives in science and describe the problem with using bibliometrics to determine who receives funding. Patrick explains why decentralizing science is so important, exploring how DeSci will increase the adoption of open science practices and accelerate innovation in the space. Listen in to understand how DeSci can pressure large academic journals to pay content creators for their work and learn how ResearchHub is leveraging Web3 to make capital available to scientists. Topics Covered How Patrick defines sciencePursuit of knowledgeVerifiable results What’s behind the replication crisis in scienceHypercompetitive job marketQuality judged by bibliometrics Why decentralizing science is importantTweak analyses to maximize perceived impactNot honest, transparent or reproducibleOnly most cited scientists receive funding Patrick’s take on the first breakthrough for DeSciIncrease adoption of open science practicesNo longer career risk to share work in open What drives Patrick’s conviction around DeSciSuccess not based on work ethic, intelligenceLittle innovation in drugs for mental health How ResearchHub rewards quality scienceAllows anyone to share and discuss papersEarn ERC-20 tokens for participation How Patrick builds trust in the scientific communityProvide funding and publishing outletsHelp meet goals of open science What success looks like for decentralized sciencePaywall journals provide open access optionsPay science content creators for work Why the science incentive structure hasn’t changedPrevious attempts not fundablePirate organizations like Sci-Hub not legal Patrick’s take on what makes publishers the enemyResponsible to own incentive to make moneyCharge scientists to publish, subscription fees Patrick’s uniting purpose for the DeSci communityWeb3 offers ROI to invest in scienceMakes capital available to scientists How Patrick defines success for ResearchHubTake power away from bibliometricsCreate rockstar scientists who define culture Connect with Patrick Joyce ResearchHub https://www.researchhub.com/ ResearchHub on Twitter https://twitter.com/researchhub ResearchHub on Discord https://discord.com/invite/ZcCYgcnUp5ResearchHub on Medium https://medium.com/researchhubResearchHub on Reddit https://www.reddit.com/r/ResearchHub/ResearchHub on GitHub https://github.com/ResearchHub Resources Brian Armstrong & Patrick Joyce on The Sheekey Science Show https://www.youtube.com/watch?v=1FmhHLPrUIUClarivate Analytics https://clarivate.com/OpenAlex https://openalex.org/r/medicalstudent https://www.reddit.com/r/medicalstudent/r/ImmunoPsychiatry https://www.reddit.com/r/ImmunoPsychiatry/eLife https://elifesciences.org/Open Science Framework https://www.cos.io/Nature Neuroscience https://www.nature.com/neuro/Chris Hill on Boost VC DeSci EP02 https://www.boost.vc/podcastAuthorea https://www.authorea.com/F1000Research https://f1000research.com/Sci-Hub https://sci-hub.se/Stack Overflow https://stackoverflow.com/Hindawi https://www.hindawi.com/MetaMask https://metamask.io/Fast Grants https://fastgrants.org/Kaggle https://www.kaggle.com/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

The system for publishing scientific research is broken. Academic success is measured by citations rather than scientific quality. And publishing companies have a monopoly on the knowledge scientists produce. Can we use blockchain technology to promote the verifiability of scientific findings? And make science accessible to everyone? Dr. Christopher Hill is an interdisciplinary scientist with a background in neuroeconomics and machine learning. Phillip Koellinger is Professor of Social Science Genetics in the Department of Economics at Vrije Universiteit Amsterdam. Together, Chris and Philipp are Cofounders of DeSci Labs, an initiative that aims to make science more replicable, accessible, transparent and fair by way of Web3 technologies. On this episode of Boost VC, Chris and Philipp join us to explain what inspired their interest in decentralized science and explore what differentiates success for science versus individual scientists. They walk us through the goals of the open science movement and weigh in on how DeSci tech provides new ways of funding research and makes scientific knowledge available to everyone. Listen in for insight around the grassroots movement known as metascience and learn how DeSci is working to improve the quality of the scientific record and reward scientists for the value they create. Topics Covered What inspired Chris & Philipp’s interest in decentralized scienceBureaucracy and broken publishing system in academiaPassionate about open science, reproducibilityImprove durability and quality of scientific recordUplift material conditions of early-career scientists The goals of the open science movementMake research more transparent, accessible to everyoneBetter markers of scientific quality than impact factorImprove and promote verifiability and reproducibility What differentiates success for science vs. success for scientistsScientific success = verifiable new knowledgeSuccess for scientist = prestige How Chris & Philipp define decentralized scienceTech stack for true open access to researchMakes science more transparent and reproducibleAllows scientists to recapture value they create The problem with measuring value by impact factor (IF)Metric derived exclusively from citation ratesPublishers have monopoly on scientific knowledge How DeSci technologies can benefit scientific researchAccelerate pace of knowledge progress and accessibilityProvide new ways of funding researchBusiness models that reward scientists for contributionsPotential for rapid experimentation at scaleCreate accountability in peer review process The interdisciplinary grassroots movement of metascienceCheck work of other scientists through replicationsConduct basic hygiene of scientific ecosystem The transition from scientific manuscripts to research objectsStore artifacts of journey, including peer review feedbackPermanent knowledge graphs to secure scientific record Connect with Chris Hill & Philipp Koellinger DeSci Labs https://www.desci.com/DeSci Labs on Twitter https://twitter.com/descilabsDeSci Foundation https://descifoundation.org/DeSci Foundation on Twitter https://twitter.com/DeSciFoundation Resources David Deutsch https://www.daviddeutsch.org.uk/‘Raise Standards for Pre-Clinical Cancer Research’ in Nature https://www.nature.com/articles/483531a‘Why Most Published Research Findings Are False’ in PLOS Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182327/Gitcoin https://gitcoin.co/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/