Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML
May 30, 202418m 59s
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Show Notes
In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone demethylase PHF8, which has been identified as a master regulator of cell-intrinsic immune responses in acute myeloid leukemia.
Featured Articles:
- Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial
- Germline genetic NBN variation and predisposition to B-cell acute lymphoblastic leukemia in children
- Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia
Topics
hematologyoncologymedicalmedical researchlymphomaleukemiaCAR Tred cells