CD8+ T-cell differentiation and treatment response in AML; ATM germline pathogenic variants affect cancer outcomes in ataxia-telangiectasia; efficacy of a selective menin-KMT2A inhibitor in KMT2A- and NPM1-altered leukemias
September 12, 202422m 42s
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Show Notes
In this week's episode we’ll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias.
Featured Articles:
- CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
- ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological
malignancies - Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in
KMT2A- and NPM1-altered leukemias
Topics
hematologyoncologymedicalmedical researchlymphomaleukemiaCAR Tred cells