Episode 15. Management of Newly Diagnosed DLBCL (Including Bonus ASH22 Updates)
Blood Cancer Talks · Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff
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Show Notes
In this episode, we discuss the management of newly diagnosed DLBCL with Dr. Pallawi Torka. We also have a few bonus ASH22 updates on DLBCL. Links to articles and abstracts discussed in the episode are as follows:
1. A comprehensive review article on DLBCL:
https://pubmed.ncbi.nlm.nih.gov/33657296/
2. RCT testing CHOP vs Three Intensive Regimens in DLBCL:
https://www.nejm.org/doi/full/10.1056/nejm199304083281404
3. RCT testing R-CHOP vs CHOP in DLBCL in older adults:
https://www.nejm.org/doi/full/10.1056/nejmoa011795
4. RCT testing R-CHOP vs CHOP in young (MINT):
https://pubmed.ncbi.nlm.nih.gov/21940214/
5. PHOENIX trial: R-CHOP +/- Ibrutinib:
https://pubmed.ncbi.nlm.nih.gov/30901302/
6. R-CHOP +/- Lenalidomide (ECOG-ACRIN E1412):
https://pubmed.ncbi.nlm.nih.gov/33555941/
7. R-CHOP vs Pola-R-CHP (POLARIX Trial):
https://www.nejm.org/doi/full/10.1056/NEJMoa2115304
8. Comparison of 3 IPI scores in DLBCL:
https://ashpublications.org/blood/article/135/23/2041/452696
9. RCT testing R-CHOP vs Dose-Adjusted R-EPOCH (CALGB 50303):
https://ascopubs.org/doi/full/10.1200/JCO.18.01994
10. Timing of CNS Prophylaxis in DLBCL:
https://pubmed.ncbi.nlm.nih.gov/34995350/
11. RCT testing R-CHOP vs R-CHOP + Bortezomib (REMoDL-B):
https://pubmed.ncbi.nlm.nih.gov/30948276/
12. Interim PET in DLBCL?
https://ashpublications.org/bloodadvances/article/5/9/2375/475850
13. RCTs in Limited Stage DLBCL:
CHOP x 8 vs CHOP x 3 + XRT (S8736):
https://ascopubs.org/doi/10.1200/JCO.2015.65.4582
CHOP x 4 + Rituximab x 6 vs R-CHOP x 6 (FLYER):
https://pubmed.ncbi.nlm.nih.gov/31868632/
PET-adapted therapy with R-CHOP (S1001):
https://pubmed.ncbi.nlm.nih.gov/32658627/
14. ASH 2022 updates:
REMoDL-B update: https://ashpublications.org/blood/article/140/Supplement%201/1770/493225
Glofitamab update: https://ashpublications.org/blood/article/140/Supplement%201/1062/491024
Epcoritamab update: https://ashpublications.org/blood/article/140/Supplement%201/9443/488543