Episode 10. Castleman Disease
In this episode, we talk Castleman Disease with Dr. Aaron Goodman (Papa Heme). We dissect the clinical and pathological classification, protean clinical manifestations, and approach to management in this rare lymphoproliferative disorder.
Blood Cancer Talks · Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff
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Show Notes
Excellent overview of Castleman Disease: https://ashpublications.org/blood/article/135/16/1353/452573/Overview-of-Castleman-disease
International consensus guideline for treatment of Idiopathic Multicentric Castleman Disease (iMCD): https://ashpublications.org/blood/article/132/20/2115/39506/International-evidence-based-consensus-treatment
Somatic alterations in Castleman Disease:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624446/
https://www.nature.com/articles/s41375-018-0323-6
Rituximab + Liposomal Doxorubicin in HHV8-positive MCD:
https://ashpublications.org/blood/article/124/24/3544/33494/Rituximab-plus-liposomal-doxorubicin-in-HIV
RCT on Siltuximab for MCD: https://pubmed.ncbi.nlm.nih.gov/25042199/
Long-term data on Siltuximab in MCD: https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(19)30257-1/fulltext