EP230: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 1 - Dayan Goodenowe, PhD
BetterHealthGuy Podcast · Scott Forsgren, FDN-P
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Show Notes
🎧 Episode Summary
This episode explores the foundational role of lipid biology and plasmalogens in cellular health, inflammation, and neurodegenerative patterns.
Dayan Goodenowe, PhD discusses how membrane composition, oxidative stress, and environmental factors influence cellular function, along with the potential impact of plasmalogen precursor therapies on cognition, resilience, and overall system regulation.
🧭 In This Episode
- Lipid membrane composition differences across cell types and organelles
- Phospholipid bilayer structure and hydrophilic–hydrophobic organization
- Functional role of membrane lipids in cellular compartmentalization
- Variability of lipid composition within different regions of a single cell
- Impact of oxidative stress on membrane lipid composition and function
- Mechanism of phospholipid peroxidation and phospholipase-mediated removal
- Relationship between membrane rigidity and cellular signaling capacity
- Mitochondrial dysfunction and its role in the Cell Danger Response
- Nutrient and cofactor requirements for mitochondrial energy production
- Interaction between membrane lipid integrity and mitochondrial performance
- Immune activation triggered by peroxidized membrane lipids
- Functional differences between omega-9 and omega-3 plasmalogen precursors
- Role of plasmalogens in synaptic transmission and neurotransmitter release
👤 About the Guest
Dayan Goodenowe, PhD, is a neuroscientist, biochemist, inventor, and clinical research expert.
In 1999, he invented and patented ion cyclotron resonance mass spectrometry technology, enabling comprehensive monitoring of human biochemistry for the first time.
Using this technology, Dr. Goodenowe analyzed blood samples from tens of thousands of individuals of all ages and races, from multiple countries. The biochemistry of healthy individuals was compared with that of individuals experiencing a wide range of diseases. Over 20 conditions were studied, including autism, dementia, colon cancer, heart disease, and others. Differences between the biochemistry of younger and older populations, as well as associations with all-cause mortality, were also examined.
This body of research identified early biochemical patterns associated with disease and mortality risk, thereby contributing to the development of an extensive patent portfolio. These patents cover diagnostic tests for early detection and screening across numerous conditions, including specific cancers, neurological disorders, psychiatric conditions, and cardiovascular disease.
Dr. Goodenowe is also the author of Breaking Alzheimer's, which documents his research journey and examines the biochemical findings that informed his work in neurodegeneration and lipid biology.
Connect With the Guest
Website - https://drgoodenowe.com
YouTube - https://www.youtube.com/@Dr.Goodenowe
Facebook - https://www.facebook.com/drdayangoodenowe
Instagram - https://www.instagram.com/drdayangoodenowe
X - https://twitter.com/DrGoodenowe
TikTok - https://www.tiktok.com/@drdayangoodenowe
Interview Date: March 24, 2026
🔗 Related Resources
Prodrome Science Plasmalogens - https://betterhealthguy.link/Prodrome
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The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.