Stiff-Person/PERM Evaluation: Andrew McKeon, M.B., B.Ch., M.D.
Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' stiff-person assay provides comprehensive evaluation for individuals on the spectrum of stiff-person syndrome. The assay can help confirm the most-severe stiff-person phenotype — kno
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Show Notes
(0:32):
Before we get started, Dr. McKeon, could you please tell our listeners a little bit about yourself and your background?
(01:13)
How long have you been with the lab?
(01:37)
Could you describe which patients should have this testing and when should it be performed?
(01:50)
Can you tell us a little bit about this unique assay that has not only glycine receptor but also other antibody tests?
(03:12)
We offer this evaluation in both serum and CSF. Can you offer any guidance about when one is more appropriate than the other?
(04:37)
Four different antibodies are included in the stiff-person assay. Why is it most appropriate to evaluate all four? And why is this assay separate from our movement disorder evaluation that includes 20 different antibodies?
(06:19)
Is it important to include all relevant antibodies — but not those would lead physicians down a confusing path?
(07:50)
Can you give our listeners a couple examples of patient presentations that might lead a physician to order this evaluation, and a couple examples where it wouldn't be appropriate?
(09:59)
Can you give a couple examples of when a broader movement disorder evaluation would be appropriate?
(11:11)
How does this new stiff-person evaluation improve upon previous approaches? What will this new test offer to physicians?
(12:35)
What does a positive or negative stiff-person evaluation result mean for a patient's care?
(13:25)
How do alanine receptor positivity and immune responsiveness affect a patient's prognosis?
(13:58)
Can tests other than this offering from Mayo Clinic Laboratories give physicians the same answers?
(14:44)
What is the key takeaway about this test?